Two authors independently screened the titles and abstracts, followed by a full-text review of relevant articles to extract key mechanisms and clinical findings discussed in this review
It is deeply involved in the pathogenesis and progression of diseases across the gut-organ axis pulmonary diseases, including cardiovascular diseases (such as atherosclerosis, heart failure, and hypertension), renal diseases, neurodegenerative disorders, and metabolic diseases, including diabetes
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According to the SUSTAIN 6 trial, the average increase in heart rate is between 2.75-3.2 beats per minute (bpm), which is clinically insignificant. While the average heart rate increase is between two and three beats per minute, some individuals have experienced an increase of up to 10 bpm in resting heart rate after administering a 1.5 mg dose of semaglutide