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The FDA has issued warnings about adverse effects related to improperly compounded GLP-1 RAs as shortages force patients to seek alternative supplies

In this 2002 seminal veterinary journal article on the use of the LA/Ao in detecting left atrial enlargement - Left atrial to aortic root indices using two-dimensional and m-mode echocardiography in cavalier king charles spaniels with and without left atrial enlargement - authors Kerstin Hansson, Jens Haggstrom, Clarence Kvart, and Peter Lord warned against blindly relying upon the LA/Ao as the ultimate determinant of LA enlargement

Common choices are 1mL or 2mL because they make the subsequent dosage math easy

As inflammation is attenuated, insulin signaling in peripheral tissues improves, and weight loss is facilitated, given that chronic inflammation can promote leptin resistance and dysregulated appetite control