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Postmenopausal osteoporosis (type I): After menopause, women experience a sudden drop in estrogen levels, a significant increase in osteoclast activity, accelerated bone resorption, insufficient osteoblast activity, and rapid loss of bone mass (30% -50% loss after 5-10 years of menopause), mainly in the lumbar spine and hip

In addition, radiation induces active degradation of matrix by impairing IGF1 signaling in human or pig cartilage and chondrocytes

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Even slight changes in hormone levels, however, can have a dramatic effect on your physical and emotional well-being and disrupt your sleep