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Pharmacological treatments are reserved for specific circumstances and limited to licensed medications with demonstrated efficacy and safety profiles, such as orlistat or semaglutide (NICE TA875)

Abrupt discontinuation can trigger withdrawal seizures, requiring gradual tapering over 1-2 weeks even after short-term use, making medical oversight essential

Cognitive Support Higher NAD levels activate sirtuins 10 (SIRT1, SIRT3), which protect brain cells by reducing oxidative stress, supporting DNA repair, and improving mitochondrial health

But we dont yet have the robust human trials that would allow us to say this is established mainstream medicine. That distinction matters