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Sobo may review the patients weight history, medication response, appetite, food noise, side effects, nutrition, protein intake, activity level, sleep, stress, current medications, labs, and long-term goals

Similarly, semaglutide reduces plaque size and burden, as well as downregulates a pro-inflammatory gene program, in mice

First-line therapy Offer metformin modified-release (M/R) and SGLT2 inhibitor dual therapy first-line, even if no other comorbidity is present, unless contraindicated (caution with SGLT2is in those with frailty)

It plays a vital role in stimulating insulin secretion, slowing gastric emptying, and reducing appetite, thus helping maintain balanced blood sugar levels and supporting weight management