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Consistently, WKY rats show poor response to conventional antidepressants but retain sensitivity to subacute ketamine, rTMS, ECT, and vmPFC DBS 24,26,34,35,36,37 , reinforcing the translational relevance of this model for investigating TRD-related mechanisms and testing novel therapeutic strategies

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The crystallization process disrupts molecular integrity

1183 These inhibitors affect key mitochondrial genes and increase OXPHOS and ATP production while reducing the expression of genes related to glycolytic pathways and related genes