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They interact with receptors across multiple systems, including the pancreas, brain, and gastrointestinal tract, to coordinate the regulation of glucose balance, appetite behavior, and digestive timing

The combination of reduced caloric intake (from appetite suppression) plus enhanced fat-burning capacity (from metabolic remodeling) produces the rapid, sustained results observed in trials

In June 2023, The New England Journal of Medicine published Eli Lilly and Company's Phase 2 clinical trial data on Retatrutide (LY3437943) online

Before initiating treatment with Wegovy, healthcare providers should assess patients for contraindications and consider individualized treatment goals, comorbidities, and preferences