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Description

Gradual shifts (adjusting timing by 12 hours per day) maintain more consistent metabolic signaling throughout the transition

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Proc Natl Acad Sci 97:68746879 Shiota C, Larsson O, Shelton KD et al (2002) Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

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Novo Nordisk filed an NDA for the CagriSema combination in December 2025, with an FDA decision anticipated in late 2026

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This is particularly relevant when tirzepatide is used in combination with insulin or sulfonylureas

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