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Using those data, researchers simulated seven clinical trials to assess how GLP-1 drugs appeared to affect existing substance use disorders and the development of new ones across alcohol, cannabis, cocaine, nicotine and opioids

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Limitations: Clinical studies of topical spironolactone are limited by the small number of patients and wide range of formulations evaluated

Therefore, the findings can likely be applied to other GLP-1 agonists beyond tirzepatide