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The SELECT trial (N=17,604), published in the New England Journal of Medicine in 2023, showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in overweight or obese adults without diabetes over a median follow-up of 34.2 months

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Second-generation antihistamines such as cetirizine, loratadine, and fexofenadine are generally preferred for their improved safety profile and minimal cardiovascular effects, and are recommended as first-line options in NICE Clinical Knowledge Summaries for allergic rhinitis

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