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Its mechanism of action includes: Appetite regulation : Acting on receptors in the hypothalamus to reduce hunger and increase satiety Gastric emptying : Slowing the rate at which food leaves the stomach, prolonging feelings of fullness Glucose homeostasis : Enhancing insulin secretion and suppressing glucagon release in a glucose-dependent manner The delayed gastric emptying effect is particularly relevant when considering drug interactions

Combining incretin-based drugs and RAAS inhibitors: more cons than pros

Mounjaro shouldn't be used in patients with, or who have a family history of, certain types of thyroid cancer such as medullary thyroid carcinoma, or in patients with multiple endocrine neoplasia type 2 (a genetic disorder of the endocrine glands), says Florence Comite, MD, an endocrinologist who is the founder of the Comite Center for Precision Medicine and Healthy Longevity in New York City