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In addition to soluble cytokines, synovium-cartilage communication is increasingly recognized to be mediated by extracellular vesicles and exosomes carrying microRNAs, long non-coding RNAs, and bioactive proteins (Wessler and Meisner-Kober, 2025

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After an incubation of 20 minutes, in which GSH is transformed into a fluorescent product, a precipitation reagent is added to separate higher molecular substances