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Reports of severe adverse events include allergic reactions ranging from mild rashes to anaphylactic shock, kidney dysfunction particularly with high doses or prolonged use, liver toxicity in susceptible individuals, and thyroid dysfunction affecting hormone regulation

However, although the bioavailability of SRT2104 (14%) is significantly higher than that of resveratrol, further improvement is needed to support broader clinical applications

A 25-year-old with normal GH levels tends to see less dramatic changes than a 50-year-old with age-related GH decline