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Of those three doctors, one said shed take the study with a large grain of salt. Another plainly called it garbage. The companies also pointed to a study showing the importance of exercise in maintaining weight loss, and to data published by one another that has not been peer-reviewedthe Calibrate data on 109 customers, and Emblas tracking of 85 of its GLP-1 users, who it said had maintained a stable body weight for 26 weeks after going off the medication

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Currently, another small molecule GLP-1R agonist called compound 29 (DA-302168S) has also shown good therapeutic potential (Dong et al., 2025)