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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )

Data availability The atomic coordinates and the electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession number 7D68 and Electron Microscopy Data Bank (EMDB) under accession number EMD-30590, respectively

Significant results (10 to 20% body weight reduction) are seen by months 3 to 6 depending on the medication and individual response

a double-edged sword of both untreted disease and treatment with gluten-free diet, Clinical Nutrition, Vol