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Our study importantly suggests that the beneficial effects on mental health were not entirely explained by weight loss

10.1016/j.healun.2007.04.006 J Heart Lung Trans

Patients should receive clear instructions regarding symptoms or changes that should prompt immediate medical evaluation, and healthcare providers should maintain heightened vigilance for potential adverse effects

Also, because GLP-1 drugs engage the brains reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people