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Market perspective Fast-track approval reflects urgency in tackling obesity Oral therapies may capture ~20% of the market by 2030 Expands access for patients preferring pills over injections While Novo Nordisk may offer slightly higher weight loss with its oral option, ease of use and flexibility position this therapy as a strong competitor

Effects of GLP-1 on gastricemptying, antropyloric motility, and transpyloric flow in response to a nonnutrient liquid.Dig Dis Sci 43:1133-1140

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The process of metformin exerting its extensive effects cannot be separated from the regulation of gut microbiota