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For a drug to passively diffuse through this layer, it typically needs to be: Small in molecular size Lipophilic (fat-soluble) However, GLP-1 molecules: Are too large and hydrophilic Cannot naturally penetrate the skin barrier Even if GLP-1 patches claim to have GLP-1 drugs, the molecules cannot pass through the skin barrier without support

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faqs GLP-1 microdosing is the use of very low, personalized doses of GLP-1 receptor agonists to support appetite control, blood sugar balance, and fat loss while minimizing side effects commonly seen with standard dosing