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The first argument that disputes the progenitor function is the considerable difference in cell morphology and size of CLCs (1723 m) and NCs (2585 m) [1, 8]

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Interestingly, most of the differentially expressed CSEPs were represented in only four clusters (clusters 1, 4, 5 and 7), all of which show peak expression in the mid and/or late stages of disease development ( Figure 4 )