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The discussion extends to broader economic and societal trends, with Dalio examining the potential decline of American and British global influence, the rise of China, and growing wealth inequality

He explores how to build and interpret a meaningful family health history, how individual risk tolerance influences decisions around testing and treatment, and why heart disease remains poorly prevented despite available tools

Initial studies were conducted in animal models and progressed to human clinical observations, with particularly strong work on immune function, longevity markers, and circadian regulation