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Demonstrated Safety and Tolerability Profile 1 With RADICAVA , the most common adverse reactions were contusion, gait disturbance, and headache 1, a (see footnote) Safety profile was demonstrated in pooled placebo-controlled trials b (see footnote) in which 184 patients with ALS were administered RADICAVA (edaravone) (60 mg) in 24-week treatment cycles

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Typical dosing range: 200-1000 mcg subcutaneously, five nights on/two nights off, with initial dosing for females often starting at 0.1-0.3 mg daily and adjusted based on individual response and lab findings