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The Research: Two Studies, One Conclusion Stanford Medicine researchers published findings in Genome Medicine (March 2026) identifying PAM gene variants particularly p.S539W and p.D563G that cause a phenomenon they call "GLP-1 resistance." People with these variants produce higher levels of GLP-1 hormone but get less biological effect from it

Body weight can influence dosing for some compounds, but many longevity-protocol formats use a fixed dose within a typical range rather than a weight-based one