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2.4.1 Background MS is an autoimmune disease of the CNS, whose hallmark is the demyelination and consequent damage to the demyelinated axons

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49 mtDNA point mutations and deletions increase exponentially with age, disrupt the assembly of the oxidative phosphorylation complex, reduce adenosine triphosphate (ATP) and increase electron leakage, and form a vicious cycle of ROS-damage-ROS

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Some probiotics can reduce the production of reactive oxygen species, enhance the activity of superoxide dismutase, glutathione peroxidase and other antioxidant enzymes (Ghoneim and Moselhy, 2016

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In the Kidneys Development of the capillaries of the kidney glomerulus depends on IGF-1 levels

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