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Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that targets areas of the brain involved in appetite regulation and food intake

The control group received saline injections on the same schedule

Significant functional decline warrants immediate medical attentionthis includes new difficulty climbing stairs, rising from a chair without assistance, carrying groceries, or performing routine daily activities that were previously manageable

Upregulated gene sets included those associated with GPCR signaling, neuropeptide receptor interactions and ligand binding, cilia formation, metabolic processes, and endocrine function Supplemental Figure 5B)