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The product values were calculated on HPLC peak areas and integrated with OriginPro 8.5 software (Northampton, MA, USA)

Statistical analyses As Pearson correlation coefficients between the nine metabolite concentration values (three metabolites in three voxels) were substantial even after adjustment for potential confounders, we used principal component analysis (PCA) to identify latent metabolite variables, and extracted scores for each component (see Results and SA7 for details)

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