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2 The relationship between the PD and the gut-microbiome-brain axis 2.1 Relationship between PD and brainstem nuclei As a key structural component of the MGBA, the VN contains circuitry involving critical brainstem nuclei: the Nucleus Tractus Solitarius (NTS), Locus Coeruleus (LC), and dorsal motor nucleus of the vagus (DMV) (18, 19)

NADH and succinate are soluble in the mitochondrial matrix, while CoQ is a small, mobile carrier that transfers electrons between the primary dehydrogenases of complexes I and II and cytochrome b