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Star Performers in the GLP-1 Space Ozempic, Mounjaro, Wegovy, and Zepbound have firmly established themselves among the top-selling pharmaceutical products globally, reflecting the rapid expansion and commercialization of the GLP-1 therapy class

In vitro experiments further revealed that under high glucose conditions, marked increase in the expression of TRIM32 along with a concomitant downregulation in the AKT and mTOR phosphorylation levels was observed, which further exacerbated pancreatic cell autophagy and hampered insulin secretion, thereby promoting development of type 2 diabetes

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They are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)