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If you miss a dose by one or two days, take it as soon as you remember, then continue your regular schedule the following week

If the allodynia is severe enough to significantly impair quality of life, temporary discontinuation allows the nervous system to reset

An international study of 17,000 people with known heart disease, overweight or obesity, but not diabetes, found that the medicine significantly lowered the chances of serious cardiovascular complications occurring

Relative contraindicationsconditions requiring closer monitoring or specialist inputinclude significant kidney impairment, active gastrointestinal disease, recent bariatric surgery, or concurrent use of certain medications that affect satiety or glucose metabolism