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Emerging small molecule inhibitors that target specific cysteine residues in redox-sensitive proteins have demonstrated promising preclinical outcomes, setting the stage for forthcoming clinical trials

UK Clinical Guidance Weight loss injections such as semaglutide (Wegovy) and liraglutide (Saxenda) are increasingly prescribed in the UK for obesity management, but their use in patients with gallstones requires careful consideration

Intranasal DEX provides reliable sedation without causing respiratory depression

We also highlight the importance of striking a balance between GLP-1 and glucagon agonism, to allow for maximal drug efficacy whilst minimising potential risks