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The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite

That is clearly unacceptable and major pressure is needed to get all companies making this class of drugs to test and validate durable and safe exit strategies

Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study

Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines