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The progression of HFL-I cells from the G1 to the S phase was blocked, resulting in a build-up of cells in the G1 phase (which were unable to enter the S phase), a relative increase in the number of cells in the G2/M phase, a decrease in the expression of Bcl-2 and survivin mRNA, an increase in the expression of Bax mRNA, and an increase in the number of apoptotic cells (Zhang, 2010)

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Because tirzepatide influences multiple metabolic pathways, some individuals notice more steady progress compared to previous treatments