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For example, a small-molecule inhibitor of p53, pifithrin-, was isolated by Komarov et al
More recently, an in vivo/in vitro study using a mouse model of focal cerebral cortical ischemia revealed that the neuroprotective effects of liraglutide (i.e., reduced brain infarct volume, improved neurological recovery, and anti-neuroinflammatory effects) may be achieved through the inhibition of pyroptosis, which is special form of apoptosis associated with inflammation and mediated by inflammasome and caspase-1 activation [94]
It is used to study GLP-1 receptor activation and its role in blood sugar regulation, insulin signaling, and appetite
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