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The slight increase in weight reduction caused by semaglutide compared to a less expensive alternative (top-dose phentermine/topiramate) does not offset semaglutide's much higher cost when considering cost and effectiveness together." Obesity treatment with drug therapy and lifestyle counselling is now recommended by the American Academy of Pediatrics for adolescents ages 12 years and older with obesity, and several medications have been approved by the FDA for use in teenagers

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[10] Patients on medications for diabetes who start ALA therapy should monitor their blood glucose closely and may need dose adjustments of their diabetic medications to prevent hypoglycemia

This trial was designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TERN-601 in healthy adults with obesity or overweight conditions