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Helping patients understand the actions of these medications can alert them to the potential gastrointestinal (GI) side effects (see sidebar Tips to Minimize GI Side Effects below)

Old ANKI mice have enhanced expression of SIRT1 target genes in the hypothalamus [83,84], which is important for physical activity and sleep quality and maintains memory and learning ability, retinal photoreceptor neurons, and further insulin secretion capacity with better glucose tolerance

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