soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm

soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm Presented at ACC.25: Among participants Oral Semaglutide and Cardiovascular Outcomes

Name: soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm Presented at ACC.25: Among participants Oral Semaglutide and Cardiovascular Outcomes
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Description

Levy 2012

For context on how these results compare with single-agonist options, semaglutide (Wegovy) achieved 14.9% mean weight loss at 68 weeks in the STEP 1 trial, and retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, showed up to 24.2% weight loss in Phase 2

They were randomized into two groups of 54, one receiving 26 weekly injections of semaglutide (2.4/mg per dose), the other receiving placebo injections

Long-term success depends on consistent dosing, regular meal patterns, and staying hydrated, since these factors support optimal GLP-1 receptor activation