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Mechanisms of Incretin-based Therapies Physiological overview: after nutrient ingestion, intestinal K cells secrete glucose-dependent insulinotropic polypeptide (GIP) and L cells release glucagon-like peptide-1 (GLP-1)

Semaglutide mimics a hormone called GLP-1, which controls appetite, food intake, and digestion

The most common side effects of GLP-1s may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, gas, stomach flu, and heartburn

In some cases, the brand-name drug and the biosimilar version may come in different forms and strengths