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Research on the association between birth defects and seizure medications include the following: In 2010, Janssen Pharmaceuticals (formerly Ortho McNeil Janssen Pharmaceuticals) was ordered to pay $81 million to resolve criminal and civil liability arising from the illegal promotion of Topamax

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The Theory of Slower Absorption One hypothesis for why the thigh might produce fewer side effects is that the absorption might be slightly slower due to the different blood flow and fat density in the legs compared to the abdomen