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Performance testing: Standardized exercise tests like time trials, max heart rate sustainable pace, or strength benchmarks document performance changes objectively

29 This condition is characterized by rapid heartbeat, sweating, nervousness, tremors, muscle weakness, sleep difficulties, increased appetite, and sudden weight loss

The first study, conducted in male mice, found that exenatide treatment did not significantly alter morphine-conditioned place preference, intravenous self-administration of the short-acting synthetic opioid remifentanil, morphine-induced locomotor activity, or the somatic signs of morphine withdrawal.163 Additionally, exenatide did not significantly affect the analgesic efficacy of morphine in the hot-plate test.163 Notably, remifentanil self-administration was comparable to or increased in mice lacking central nervous system GLP-1 receptors relative to wild-type controls.163 It is important to acknowledge that the association between GLP-1RAs and suicidal behavior has not been sufficiently studied

Emotional sensitivity Increased emotional responsiveness or mood fluctuations may occur as hippocampal connectivity changes