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While these findings are promising, animal studies do not always translate directly to humans, so more research is needed in people with RA to confirm these results

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In phase 3 clinical trials, tirzepatide improved liver fibrosis in individuals with metabolic dysfunction-associated steatohepatitis (MASH) 4 , and outperformed semaglutide in the management of obesity 1 and type 2 diabetes 2

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