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The tendency for desmoplastic melanoma to manifest neurotropism and stromal collagenization can be explained at the molecular level by gene expression profiling that shows activation of genes encoding for neurotrophic factors and for extracellular matric elaboration, 32 expressed at the protein level in fixed tissues by immunohistochemical assay for p75 nerve growth factor receptor, 33 basic fibroblast growth factor (b-FGF) 34 and the fibroblastic markers CD90 and CD13