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Similarly, the oral GLP-1 RA will also need to demonstrate their cardiovascular safety in these populations (NCT05803421)

VPA-exposed rats spent significantly less time in the target quadrant compared to controls ( P 0.05 )

Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains