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For instance, ROS exposure in HLE and SNU cells upregulates cyclin D1 and activates the PI3K/AKT pathway, effects that are completely abolished by N-acetylcysteine or catalase, confirming their ROS dependency[89]

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Salviolone, a bisnorditerpene compound derived from Salvia miltiorrhiza and Salvia paramiltiorrhiza, has been shown to have inhibitory effects on melanoma cells by inhibiting matrix metalloproteinase 2 activity and the STAT3 pathway [41]

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