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Bain MA, Milne RW, Evans AM (2006) Disposition and metabolite kinetics of oral L-carnitine in humans

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Dexpramipexole also prevented functional decline in a dose dependent manner compared to placebo (Cudkowicz et al., 2011)

In addition to providing biosynthetic substrates and energetic support for macrophages, distinct amino acid metabolic pathways can also reshape the inflammatory and reparative functional states of macrophages by regulating redox homeostasis, epigenetic modifications, signal transduction, and the accumulation of metabolic intermediates