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In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

Exclusion of patients of the following cardiovascular diseases was defined as low risk of cardiovascular disease (such as myocardial infarction, heart failure, coronary heart disease, stroke, angina pectoris and other serious cardiovascular disease)

Curr Opin Cardiol (2019) 34(6):68792

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