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Behavioral investigations of GLP-1 and palatable food intake also reported that injection of exendin-4 (Ex-4) (1 or 3.2 g/kg IP doses only and not higher doses) also changed acquisition of food aversion learning (Liang et al., Neuroanatomical Pathways About GLP-1 and Palatable Food Intake Many studies investigated the role of GLP-1R modulation in different neuroanatomical areas on palatable food intake (Supplementary Table 1)

The leading example is its co-development with cagrilintide (formerly AM833), a long-acting analogue of amylin, the hormone co-secreted with insulin that slows gastric emptying, suppresses glucagon after meals and enhances meal-related satiety

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It cautions that real-world effectiveness often differs from controlled trial results because of adherence and lifestyle factors