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doi: 10.1016/j.tem.2019.09.003

A role in tumor development in patients with T2DM is also being investigated but further studies are required to fully understand the functions of GLP-1R and its agonists

Tirzepatide operates through dual GLP-1 and GIP receptor agonism , a mechanism that already outperforms standalone GLP-1 drugs like semaglutide in head-to-head trials

If you experience severe, persistent abdominal pain while taking a GLP-1 receptor agonist, seek urgent medical attention