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reported in an early study that Fas signaling stimulation did not lead to caspases recruitment in erythrocytes [182], it was later demonstrated that phosphatidylserine translocation to the outer membrane in RBCs was regulated by the assembly of the Fas/FADD/caspase-8 complex and downstream activation of caspase-3 [191]

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We previously reported that reduced levels of activated hepatocyte growth factor and the c-Met receptor tyrosine kinaseboth of which are vital for maintaining cellular redox balancecombined with increased expression of GJ proteins in hepsin-deficient mice