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Common CNS causes include: Stroke or TIA sudden interruption of blood flow to the brain, producing one-sided weakness or numbness, facial drooping, or speech difficulty Multiple sclerosis demyelination in the brain and spinal cord causing episodic or progressive numbness, weakness, and balance problems Spinal cord compression from injury, tumor, or severe disc disease, producing weakness and numbness below the level of compression Brain tumors depending on location, can cause focal weakness, sensory changes, or coordination problems Distinguishing peripheral from central causes guides the urgency and type of workup needed