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Notably, during tissue repair in later inflammation stages, the inflammatory cells produce excess ROS accumulation, it can cause irreversible DNA damage in new cells, such as deletions, point mutations and rearrangements 58 (Figure 2)

Rigamonti AE, Agosti F, Compri E, et al

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Of note, a feed-forward loop may occur whereby IL-1 itself triggers further mtDNA release, sustaining inflammation (44, 45)