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C., Wong, Z
Macrophage-mediated iron release can promote muscle regeneration, while selective inhibition of macrophage iron output can inhibit muscle regeneration and cause fat accumulation
The major manufacturing challenges associated with amylin analogs stem from the intrinsic tendency of the native amylin peptide to aggregate into amyloid fibrils in physiological conditions, which requires comprehensive chemical modifications to develop stable, soluble amylin analogs with favorable shelf life and patient tolerability to be manufactured commercially
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